May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. Stimulates transcription activity of the RNA polymerase I complex. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. b Prvo otkrie je napravio Albert Marth 26. Najvei prenik je 0,90 a najmanji 0,3 uglovnih minuta. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. NGC 5973 je spiralna galaksija koja je udaljena oko 168 miliona sg od Zemlje i nalazi se u sazvijeu Vaga. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. SIRT7 thereby acts as a transcription repressor. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors.

In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac).

SIR2L7 NAD-dependent protein deacetylase sirtuin-7 Regulatory protein SIR2 homolog 7 SIR2-like protein 7 SIRT7 Aliquot into multiple vials to avoid repeated freeze-thaw cycles. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors.KLH conjugated synthetic peptide derived from human SIRT7Īqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Target Gene ID Swiss Prot Subcellular location Cytoplasm, Nucleus Synonyms SIR2L7 NAD-dependent protein deacetylase sirtuin-7 Regulatory protein SIR2 homolog 7 SIR2-like protein 7 SIRT7 Background NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Overview: Catalog bs-5973R-PE: Product Name: SIRT7 Polyclonal Antibody, PE Conjugated: Applications: FCM: Reactivity: Mouse: Predicted Reactivity: Human, Rat, Dog. Overview Catalog # bs-5973R Product Name SIRT7 Polyclonal Antibody Applications WB, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F) Reactivity Human, Mouse, Rat Specifications Conjugation Unconjugated Host Rabbit Source KLH conjugated synthetic peptide derived from human SIRT7 Immunogen Range 250-300/400 Clonality Polyclonal Isotype IgG Concentration 1ug/ul Purification Purified by Protein A.

Catalog BS 5973